Description
Recombinant human EPHB2 (570-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_004442.
EPHB2 is a member of the EpHfamily of receptor tyrosine kinases that mediate neurodevelopmental processes such as boundary formation, axon guidance, vasculogenesis, and cell migration. EPHB2 has been shown to associate with the non-receptor tyrosine kinase Abl and activated EPHB2 causes tyrosine phosphorylation of Abl and regulates its activity (1). EPHB2 is overexpressed in a number of tumors particularly glioblastoma and this increases glioma cell migration and invasion (2)